Article
In vivo optical imaging of LacZ expression using lacZ transgenic mice.
Assay and drug development technologies - 1 Aug 2009
Zhang Guo-Jun, Chen Tsing-Bau, Connolly Brett, Lin Shu-An, Hargreaves Richard, Vanko Amy, Bednar Bohumil, Macneil Douglas J, Sur Cyrille, Williams David L
Abstract excerpt
beta-Galactosidase (beta-gal) (encoded by the lacZ gene) has been widely used as a transgene reporter enzyme. The ability to image lacZ expression in living transgenic animals would further extend the use of this reporter. It has been reported that 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one)-beta-d-galactopyranoside (DDAOG), a conjugate of beta-galactose and...
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