Article
Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein.
Scientific reports - 10 Jun 2015
Inagaki Yoshinori, Matsumoto Yasuhiko, Ishii Masaki, Uchino Keiro, Sezutsu Hideki, Sekimizu Kazuhisa
Abstract excerpt
In drug development, the toxicity of candidate chemicals must be carefully examined in an animal model. Here we developed a live imaging technique using silkworms for a noninvasive toxicity test applicable for drug screening. Injection of carbon tetrachloride, a tissue-injuring chemical, into transgenic silkworms expressing green fluorescent protein (GFP) induced leakage of GFP from the tissues into the...
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