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Article

Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2014

Santa Maria John P, Sadaka Ama, Moussa Samir H, Brown Stephanie, Zhang Yanjia J, Rubin Eric J, Gilmore Michael S, Walker Suzanne

Abstract excerpt

Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundant roles in regulating cell division. To gain insight into the underlying biology of S. aureus TAs, we used a small molecule inhibitor to screen a highly saturated transposon library for cellular factors that become essential when WTA is depleted. We...

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Identifiers

PMID: 25104751
DOI: 10.1073/pnas.1404099111
PMCID: PMC4151746

Genes

LTA

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