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Article

A synthetic lethal approach for compound and target identification in Staphylococcus aureus.

Nature chemical biology - 1 Jan 2016

Pasquina Lincoln, Santa Maria John P, McKay Wood B, Moussa Samir H, Matano Leigh M, Santiago Marina, Martin Sara E S, Lee Wonsik, Meredith Timothy C, Walker Suzanne

Abstract excerpt

The majority of bacterial proteins are dispensable for growth in the laboratory but nevertheless have important physiological roles. There are no systematic approaches to identify cell-permeable small-molecule inhibitors of these proteins. We demonstrate a strategy to identify such inhibitors that exploits synthetic lethal relationships both for small-molecule discovery and for target identification. Applying...

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Identifiers

PMID: 26619249
DOI: 10.1038/nchembio.1967
PMCID: PMC4684722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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