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Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

22 Mar 2023

Abstract excerpt

Phenol-soluble modulins (PSMs) and Staphylococcal protein A (SpA) are key virulence determinants for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), an important human pathogen that causes a wide range of diseases. Here, using chemical and genetic approaches, we show that inhibition of TarO, the first enzyme in the wall teichoic acid (WTA) biosynthetic pathway, decreases the expression...

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PMID: 36949052
DOI: 10.1038/s41467-023-37310-5

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