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Article

Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation.

Antimicrobial agents and chemotherapy - 1 Nov 2009

Qian Yaping, Guan Min-Xin

Abstract excerpt

The mitochondrial 12S rRNA A1555G mutation is one of the important causes of aminoglycoside-induced and nonsyndromic hearing loss. Here we employed an RNA-directed chemical-modification approach to understanding the pathogenesis of aminoglycoside-induced hearing loss. The patterns of chemical modification of RNA oligonucleotides carrying the A1555G mutation by dimethyl sulfate (DMS) were distinct from those of...

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Identifiers

PMID: 19687236
DOI: 10.1128/AAC.00965-08
PMCID: PMC2772318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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