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Article

[Mitochondrial tRNAThr G15927A mutation may influence the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation.].

Yi chuan = Hereditas - 1 Oct 2008

Tang Xiao-Wen, Li Zhi-Yuan, Lu Jian-Xin, Zhu Yi, Li Rong-Hua, Wang Jin-Dan, Guan Min-Xin

Abstract excerpt

We report here the clinical and genetic evaluations as well as mutational analysis of mitochondrial DNA (mtDNA) in a four-generation Chinese Han family with aminoglycoside-induced and nonsyndromic hearing loss. Strikingly, this family exhibited a high penetrance and expressivity of hearing loss. The penetrances of hearing loss in this family were 75% and 41.7% respectively, when aminoglycoside-induced deafness...

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Identifiers

PMID: 18930888
DOI: 10.3724/sp.j.1005.2008.01287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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