Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.

Human molecular genetics - 15 Feb 2015

O'Sullivan Mary, Rutland Paul, Lucas Deirdre, Ashton Emma, Hendricks Sebastian, Rahman Shamima, Bitner-Glindzicz Maria

Abstract excerpt

The mitochondrial DNA mutation m.1555A>G predisposes to hearing loss following aminoglycoside antibiotic exposure in an idiosyncratic dose-independent manner. However, it may also cause maternally inherited hearing loss in the absence of aminoglycoside exposure or any other clinical features (non-syndromic hearing loss). Although m.1555A>G was identified as a cause of deafness more than twenty years ago, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Family
Share to Genes, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Hearing Loss

Share to Infant

Share to Methylation

Share to Nucleic Acid Conformation

Share to RNA, Ribosomal

Source

Open in PubMed Open full text

Identifiers

PMID: 25305075
DOI: 10.1093/hmg/ddu518
PMCID: PMC4986548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.PMID 25305075Read ↗

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity.Semantic proximity Read ↗

Genetics of aminoglycoside-induced and prelingual non-syndromic mitochondrial hearing impairment: a review.Semantic proximity Read ↗

A maternal hereditary deafness pedigree of the A1555G mitochondrial mutation, causing aminoglycoside ototoxicity predisposition.Semantic proximity Read ↗

Prevalence and clinical features of the mitochondrial m.1555A>G mutation in Taiwanese patients with idiopathic sensorineural hearing loss and association of haplogroup F with low penetrance in three families.Semantic proximity Read ↗

Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides.Semantic proximity Read ↗

Mitochondrial 12S rRNA gene mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment.Semantic proximity Read ↗

Mitochondrial haplotypes may modulate the phenotypic manifestation of the deafness-associated 12S rRNA 1555A>G mutation.Semantic proximity Read ↗

Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.Semantic proximity Read ↗

A mutation in mitochondrial 12S rRNA, A827G, in Argentinean family with hearing loss after aminoglycoside treatment.Semantic proximity Read ↗

Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss.Semantic proximity Read ↗

Defining the cellular and molecular mechanism of maternally inherited hearing lossSemantic proximity Read ↗

Mitochondrial 12S rRNA susceptibility mutations in aminoglycoside-associated and idiopathic bilateral vestibulopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.