Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells.

doi:10.1016/0024-3205(90)90087-8

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Article

Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells.

Life sciences - 1 Jan 1990

Yamaji Y, Natsumeda Y, Yamada Y, Irino S, Weber G

Abstract excerpt

Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of guanosine. Since it has been shown that tiazofurin down-regulated the expression of c-Ki-ras...

Topics

Antineoplastic Agents
Cell Differentiation
Cell Division
Cell Transformation, Neoplastic
Clone Cells
Dose-Response Relationship, Drug
Drug Synergism
Guanosine
Humans
IMP Dehydrogenase
Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Phenotype

Ribavirin

Ribonucleosides

Time Factors

Tretinoin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1968220
DOI: 10.1016/0024-3205(90)90087-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1968220-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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