Article
Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis, respectively, in HL-60 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1996
Mehta K, McQueen T, Neamati N, Collins S, Andreeff M
Abstract excerpt
Induction of granulocytic differentiation in HL-60 myeloid leukemia cells by retinoids is followed by their death via apoptosis. Retinoids are known to mediate their biological effects through at least two distinct types of nuclear receptors, the retinoic acid receptors and retinoid X receptors. We undertook to characterize the potential role of these receptors in inducing differentiation and apoptosis by...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Antigens, CD
- Antigens, Differentiation
- Apoptosis
- Cell Differentiation
- DNA
- DNA-Binding Proteins
- Gene Expression
- HL-60 Cells
- Humans
- In Situ Hybridization
- Membrane Glycoproteins