Article
Effects of uridine on the growth and differentiation of HL-60 leukemia cells.
Leukemia research - 1 Jan 1991
Sokoloski J A, Lee C W, Handschumacher R E, Nigam A, Sartorelli A C
Abstract excerpt
HL-60 leukemia cells, induced to differentiate, activate a Na(+)-dependent nucleoside transport system, concomitant with a reduction in the nitrobenzylthioinosine (NBMPR)-sensitive facilitated transport of nucleosides. The consequence of these changes lead to the formation of intracellular pools of uridine. To examine the possible role of accumulated uridine in the commitment of HL-60 leukemia cells to undergo...
Topics
- Cell Differentiation
- Cell Division
- Cell Line
- Dose-Response Relationship, Drug
- Fluorescent Antibody Technique
- Humans
- Leukemia, Promyelocytic, Acute
- Nitroblue Tetrazolium
- Phenotype
- Ribonucleotides
- Tumor Cells, Cultured