The differentiating effect of retinoic acid and vincristine on acute myeloid leukemia.

doi:10.1089/106161299320307

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Article

The differentiating effect of retinoic acid and vincristine on acute myeloid leukemia.

Journal of hematotherapy - 1 Jun 1999

Leung M F, Wong K F

Abstract excerpt

We have shown previously that granulocytic maturation and differentiation occurred when HL-60 cells and leukemia cells from a patient with acute promyelocytic leukemia (APL) were exposed to all-trans retinoic acid (ATRA) after treatment with a noncytotoxic concentration of vincristine (VCR), suggesting that VCR might have synergistic action with ATRA in the treatment of APL. Leukemic cells obtained from 24...

Topics

Acute Disease
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Cell Differentiation
Flow Cytometry
Gene Expression
HL-60 Cells
HLA Antigens
Humans
Leukemia, Myeloid
Middle Aged
Phenotype
Tretinoin
Tumor Cells, Cultured
Vincristine

Source

Open in PubMed

Identifiers

PMID: 10417051
DOI: 10.1089/106161299320307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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