Article
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
Blood - 15 Sept 1994
Katagiri K, Hattori S, Nakamura S, Yamamoto T, Yoshida T, Katagiri T
Abstract excerpt
In this study, it was shown that the proportion of guanosine triphosphate (GTP)-bound active Ras increased in TPA (12-o-tetradecanoyl phorbol-13-acetate)-induced monocytic differentiation of HL-60 cells. The increase of active Ras was observed at 24 hours after TPA stimulation and attained to thr...
Topics
- Benzoquinones
- Cell Differentiation
- Dexamethasone
- Enzyme Activation
- GTPase-Activating Proteins
- Granulocytes
- Guanosine Triphosphate
- Humans
- Lactams, Macrocyclic
- Monocytes
- Mutation
- Oncogene Protein p21(ras)