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Article

Structure-activity Relationships of Flavonoids and the Induction of Granulocytic- or Monocytic-Differentiation in HL60 Human Myeloid Leukemia Cells

1 Jan 1998

Abstract excerpt

The flavones apigenin and luteolin strongly inhibited the growth of HL60 cells and induced morphological differentiation into granulocytes. The flavonol quercetin inhibited the cell growth and induced a differentiation marker, i.e., NBT reducing ability. However quercetin-treated cells were not morphologically differentiated into granulocytes. The chalcone phloretin weakly induced NBT reducing ability and a...

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PMID: 9972240
DOI: 10.1271/bbb.62.2199

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