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Article

Enhanced suppression of human myeloid leukemic cell lines by combinations of IL-6, LIF, GM-CSF and G-CSF.

International journal of cancer - 15 Feb 1990

Maekawa T, Metcalf D, Gearing D P

Abstract excerpt

The interactions of purified recombinant human leukemia inhibitory factor (LIF), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF) on the clonogenicity of HL60 cells and U937 cells were studied in vitro. IL-6 alone strongly suppressed colony formation by U937 cells with induction of differentiation and loss of clonogenicity. GM-CSF interacted...

Topics

Colony-Stimulating Factors
Drug Synergism
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Growth Inhibitors
Growth Substances
Humans
Interleukin-6
Leukemia Inhibitory Factor
Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphokines

Neoplastic Stem Cells

Phenotype

Tumor Cells, Cultured

Source

Identifiers

PMID: 1689277
DOI: 10.1002/ijc.2910450224

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689277-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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