Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).

PloS one - 1 Jan 2015

Odahara Shunichi, Uchiyama Kan, Kubota Takahiro, Ito Zensho, Takami Shinichiro, Kobayashi Hiroko, Saito Keisuke, Koido Shigeo, Ohkusa Toshifumi

Abstract excerpt

Azathioprine (AZA) is frequently used in patients with inflammatory bowel disease (IBD). However, toxic adverse reactions frequently develop and limit the clinical benefits. Currently, the precise mechanisms underlying thiopurine-related toxicity are not well understood. To investigate the relationship between the extent of thiopurine metabolism and adverse reactions in Japanese IBD patients, we prospectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azathioprine
Share to Guanine Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Inflammatory Bowel Diseases

Share to Leukopenia

Share to Methyltransferases

Share to Pyrophosphatases

Share to Thionucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 26360046
DOI: 10.1371/journal.pone.0137798
PMCID: PMC4567281

Genes

ITPA
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).PMID 26360046Read ↗

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.Semantic proximity Read ↗

Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.Semantic proximity Read ↗

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.Semantic proximity Read ↗

Differences in the adverse effects of azathioprine between inflammatory bowel disease and autoimmune hepatitis in Korean patients.Semantic proximity Read ↗

Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel diseaseSemantic proximity Read ↗

Monitoring thiopurine metabolites in korean pediatric patients with inflammatory bowel disease.Semantic proximity Read ↗

Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.Semantic proximity Read ↗

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.Semantic proximity Read ↗

Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease.Semantic proximity Read ↗

Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.Semantic proximity Read ↗

Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.Semantic proximity Read ↗

The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.