Article
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).
Pharmacogenetics - 1 Mar 2004
Marinaki Anthony M, Ansari Azhar, Duley John A, Arenas Monica, Sumi Satoshi, Lewis Cathryn M, Shobowale-Bakre El-Monsor, Escuredo Emilia, Fairbanks Lynette D, Sanderson Jeremy D
Abstract excerpt
Adverse drug reactions to azathioprine (AZA), the pro-drug of 6-mercaptopurine (6-MP), occur in 15% to 28% of patients and the majority are not explained by thiopurine methyltransferase (TPMT) deficiency. Inosine triphosphate pyrophosphatase (ITPase) deficiency results in the benign accumulation of the inosine nucleotide ITP. 6-MP is activated through a 6-thio-IMP intermediate and, in ITPase deficient patients,...
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