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Article

Insulin-like growth factor 1 receptor expression in wild-type GISTs: a potential novel therapeutic target.

International journal of cancer - 15 Dec 2009

Pantaleo Maria A, Astolfi Annalisa, Di Battista Monica, Heinrich Michael C, Paterini Paola, Scotlandi Katia, Santini Donatella, Catena Fausto, Manara Maria C, Nannini Margherita, Maleddu Alessandra, Saponara Maristella, Lolli Cristian, Formica Serena, Biasco Guido

Abstract excerpt

Aberrations of the Insulin-like Growth Factor (IGF) system have been found in association with a variety of cancer types. The potential role of IGF1R has been postulated in a small subset of GISTs, but until now the implications of its aberrations have not been defined. The aim of the study was to examine the IGF1R status in patients with gastric GIST in regard to KIT and PDGFRA genotype. Fresh resection...

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Source

Identifiers

PMID: 19672856
DOI: 10.1002/ijc.24595

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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