Article
Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2008
Tarn Chi, Rink Lori, Merkel Erin, Flieder Douglas, Pathak Harsh, Koumbi Daphne, Testa Joseph R, Eisenberg Burton, von Mehren Margaret, Godwin Andrew K
Abstract excerpt
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRalpha. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib-based therapies and have a poor prognosis. We identified amplification of IGF1R in a SNP analysis of GIST and thus studied its potential as a therapeutic target in WT and mutant GIST. Expression of IGF1R and downstream effectors in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.