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Article

IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting.

The Journal of pathology - 1 Jul 2010

Hajdu Mihai, Singer Samuel, Maki Robert G, Schwartz Gary K, Keohan Mary Lou, Antonescu Cristina R

Abstract excerpt

Solitary fibrous tumour (SFT) is a mesenchymal neoplasm composed of CD34-positive fibroblastic cells. The pathogenesis driving this neoplasm remains unclear, with no recurrent genetic aberrations described to date. Previous reports suggest a role for IGF2 over-expression in the pathogenesis of these tumours, implicated in triggering hypoglycaemia in some patients. The expression profiling of 23 SFTs was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20527023
DOI: 10.1002/path.2715
PMCID: PMC3264680

Genes

IGF2
DDR1
ERBB2
FGFR1
IGF1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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