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Article

Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA.

Cancer medicine - 1 Feb 2013

Beadling Carol, Patterson Janice, Justusson Emily, Nelson Dylan, Pantaleo Maria A, Hornick Jason L, Chacón Matias, Corless Christopher L, Heinrich Michael C

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal (ICCs) and are the most common mesenchymal neoplasm of the gastrointestinal tract. While the majority of GISTs harbor activating mutations in either the v-kit Hardy-Zuckerman feline sarcoma viral oncogene homolog (KIT) or platelet-derived growth factor receptor alpha (PDGFRA) tyrosine kinases, approximately 10-15% of adult GISTs...

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Topics

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Share to Antigens, CD34
Share to Gastrointestinal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Neoplasm Proteins

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, IGF Type 1

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 24133624
DOI: 10.1002/cam4.57
PMCID: PMC3797556

Genes

KIT
PDGFRA
IGF1
IGF2
INSR
CDH2
KIRREL3
LHX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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