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Article

Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2012

Italiano Antoine, Chen Junwei, Zhang Lei, Hajdu Mihai, Singer Samuel, DeMatteo Ronald P, Antonescu Cristina R

Abstract excerpt

BACKGROUND: Data regarding the patterns and the mechanisms of deregulation of the insulin growth factor (IGF) pathway in adult and paediatric gastrointestinal stromal tumours (GISTs) are limited. METHODS: We investigated the expression profiling of the genes encoding the main components of the IGF signalling pathway in 131 GISTs (106 adults, 21 paediatric and four young adults) and 25 other soft-tissue sarcomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22770876
DOI: 10.1016/j.ejca.2012.05.021
PMCID: PMC3564499

Genes

IGF2
STS
KIT
PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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