Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of IGF-1 receptor in KIT/PDGF receptor-α wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction.

Future oncology (London, England) - 1 Jan 2013

Nannini Margherita, Astolfi Annalisa, Paterini Paola, Urbini Milena, Santini Donatella, Catena Fausto, Indio Valentina, Casadio Rita, Pinna Antonio Daniele, Biasco Guido, Pantaleo Maria A

Abstract excerpt

KIT/PDGF receptor-α (PDGFRA) wild-type (WT) gastrointestinal stromal tumors (GIST) are characterized by an overexpression of IGF-1 receptor (IGF1R) at the mRNA and protein level. More recently, germline and somatic mutations in succinate dehydrogenase (SDH) subunits A, B and C have been identifie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal Stromal Tumors
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, IGF Type 1

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Succinate Dehydrogenase

Share to Young Adult

Source

Identifiers

PMID: 23252569
DOI: 10.2217/fon.12.170

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23252569-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of IGF-1 receptor in KIT/PDGF receptor-α wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction.PMID 23252569Read ↗

Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumorsSemantic proximity Read ↗

The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.Semantic proximity Read ↗

Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors.Semantic proximity Read ↗

Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA.Semantic proximity Read ↗

Succinate dehydrogenase-deficient gastrointestinal stromal tumorsSemantic proximity Read ↗

Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors.Semantic proximity Read ↗

Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST.Semantic proximity Read ↗

Classification of KIT/PDGFRA wild-type gastrointestinal stromal tumors: implications for therapy.Semantic proximity Read ↗

Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.Semantic proximity Read ↗

Genetics of Gastrointestinal Stromal Tumors: A Heterogeneous Family of Tumors?Semantic proximity Read ↗

Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review.Semantic proximity Read ↗

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.