Article
BreakDancer: an algorithm for high-resolution mapping of genomic structural variation.
Nature methods - 1 Sept 2009
Chen Ken, Wallis John W, McLellan Michael D, Larson David E, Kalicki Joelle M, Pohl Craig S, McGrath Sean D, Wendl Michael C, Zhang Qunyuan, Locke Devin P, Shi Xiaoqi, Fulton Robert S, Ley Timothy J, Wilson Richard K, Ding Li, Mardis Elaine R
Abstract excerpt
Detection and characterization of genomic structural variation are important for understanding the landscape of genetic variation in human populations and in complex diseases such as cancer. Recent studies demonstrate the feasibility of detecting structural variation using next-generation, short-insert, paired-end sequencing reads. However, the utility of these reads is not entirely clear, nor are the analysis...
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