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Article

novoBreak: local assembly for breakpoint detection in cancer genomes.

Nature methods - 1 Jan 2017

Chong Zechen, Ruan Jue, Gao Min, Zhou Wanding, Chen Tenghui, Fan Xian, Ding Li, Lee Anna Y, Boutros Paul, Chen Junjie, Chen Ken

Abstract excerpt

We present novoBreak, a genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole-genome sequencing data. novoBreak consistently outperformed existing algorithms on real cancer genome data and on synthetic tumors in the ICGC-TCGA DREAM 8.5 Somatic Mutation Calling Challenge primarily because it more effectively utilized reads spanning breakpoints. novoBreak...

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Identifiers

PMID: 27892959
DOI: 10.1038/nmeth.4084
PMCID: PMC5199621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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