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Article

Robust and exact structural variation detection with paired-end and soft-clipped alignments: SoftSV compared with eight algorithms.

Briefings in bioinformatics - 1 Jan 2016

Bartenhagen Christoph, Dugas Martin

Abstract excerpt

Structural variation (SV) plays an important role in genetic diversity among the population in general and specifically in diseases such as cancer. Modern next-generation sequencing (NGS) technologies provide paired-end sequencing data at high depth with increasing read lengths. This development enabled the analysis of split-reads to detect SV breakpoints with single-nucleotide resolution. But ambiguous mappings...

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Identifiers

PMID: 25998133
DOI: 10.1093/bib/bbv028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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