Article
High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors.
Pharmacogenomics - 1 Jan 2015
Hasheminasab Sayed-Mohammad, Tzvetkov Mladen V, Schumann Christian, Rüdiger Stefan, Boeck Stefan, Heinemann Volker, Kächele Volker, Steffens Michael, Scholl Catharina, Hichert Vivien, Seufferlein Thomas, Brockmöller Jürgen, Stingl Julia C
Abstract excerpt
AIM: To identify genomic variants in the EGFR pathway and in cytokines predisposing to skin toxicity from EGFR inhibitors. PATIENTS & METHODS: In 126 patients with cancer and EGFR inhibitor therapy skin toxicity was quantified and EGFR and inflammatory pathway genes were analyzed by deep sequencing. RESULTS: We found 1437 SNPs in the 382-kb target region. Three SNPs in EGFR intron 1 were found exclusively in...
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