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Article

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009

Jang Haeman, Boltz David, Sturm-Ramirez Katharine, Shepherd Kennie R, Jiao Yun, Webster Robert, Smeyne Richard J

Abstract excerpt

One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of the 433 known human cases of H5N1 infection have proved fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild...

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Identifiers

PMID: 19667183
DOI: 10.1073/pnas.0900096106
PMCID: PMC2729020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19667183-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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