Article

Elevated brain α-synuclein, phosphorylated-tau, and oxidative stress in mice that survived influenza A pneumonitis

2025-08-01

Abstract excerpt

Influenza virus infection increases the incidence of parkinsonism in humans. We have previously shown that allelic variants at the Parkinson’s disease (PD)-linked Lrrk2 locus modulate host responses in vivo . Here, we asked whether Lrrk2 kinase activity alters disease outcomes in adult mice that survived a nasally acquired infection. We inoculated mice with the mouse adapted A/Fort Monmouth/1/1947 influenza A vi...

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Literature Corpus work: d66ac2bf-5111-52cf-a2ef-0c6691ba07b6
DOI: 10.1101/2025.07.31.667659

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