Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

1 Jul 2025

Abstract excerpt

The highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses, responsible for the current outbreak in dairy cows in the United States, pose a significant animal and public health threat. In this study, we compare disease progression and pathology of three recent clade 2.3.4.4b isolates derived from a cow, a mountain lion, and a mink to a human HPAI A(H5N1) isolate from Vietnam in mice. Inoculating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to Influenza Virus Research Studies
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40593471
DOI: 10.1038/s41467-025-60407-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic diseasePMID 40593471Read ↗

Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolateSemantic proximity Read ↗

Highly Pathogenic Avian Influenza (H5N1) Clade 2.3.4.4b in Cattle: A Rising One Health ConcernSemantic proximity Read ↗

Emerging threats of H5N1 clade 2.3.4.4b: cross-species transmission, pathogenesis, and pandemic riskSemantic proximity Read ↗

Highly Pathogenic Avian Influenza (H5N1) in Cattle: A Rising ConcernSemantic proximity Read ↗

Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmissionSemantic proximity Read ↗

Clade 2.3.4.4b highly pathogenic H5N1 influenza viruses from birds in China replicate effectively in bovine cells and pose potential public health riskSemantic proximity Read ↗

Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaquesSemantic proximity Read ↗

Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in macaquesSemantic proximity Read ↗

Isolation and characterization of a clade 2.3.4.4b genotype D1.1 H5N1 virus from dairy cattle in Wisconsin.Semantic proximity Read ↗

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like propertiesSemantic proximity Read ↗

From birds to mammals: spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle led to efficient intra- and interspecies transmissionSemantic proximity Read ↗

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.