Article

Age-dependent Powassan Virus Lethality is Directed by Glial Cell Activation and Divergent Neuroinflammatory Cytokine Responses in a Murine Model

2023-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Powassan virus (POWV) is an emergent tick-borne flavivirus that causes fatal encephalitis in the elderly and long-term neurologic sequelae in survivors. How age contributes to severe POWV encephalitis remains an enigma and there are currently no animal models that reflect age-dependent POWV neuropathology. Inoculating C57BL/6 mice with a POWV strain (LI9) currently circulating in Ixodes ticks,...

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Literature Corpus work: 9ac52c0b-077e-55ed-9814-fceb11bc0200
DOI: 10.1101/2023.12.18.572230

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