Article
RGS2 promotes formation of neurites by stimulating microtubule polymerization.
Cellular signalling - 1 Dec 2006
Heo Kyun, Ha Sang Hoon, Chae Young Chan, Lee Sukmook, Oh Yong-Seok, Kim Yun-Hee, Kim Sun-Hee, Kim Jung Hwan, Mizoguchi Akira, Itoh Tomohiko J, Kwon H Moo, Ryu Sung Ho, Suh Pann-Ghill
Abstract excerpt
Regulator of G-protein signaling (RGS) proteins interact with alpha subunits of heterotrimeric G-proteins via the RGS domain and attenuate their activity by accelerating GTPase activity. RGS2, a member of the RGS family, regulates synaptic development via hereto unknown mechanism. In this study, we found that RGS2 directly interacted with tubulin via a short region at the N-terminus: amino acids 41-60. RGS2...
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