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Article

The signal transducer and activator of transcription 3 at the center of the causative gene network of the hyper-IgE syndrome.

Current opinion in immunology - 1 Feb 2023

Minegishi Yoshiyuki

Abstract excerpt

The hyper-IgE syndrome (HIES) is characterized by atopic dermatitis with extremely high serum IgE levels and diminished inflammatory responses, in combination with bacterial and fungal infections followed by pneumatocele formation. These immunological manifestations are frequently associated with nonimmunological abnormalities, including characteristic face, pathological fracture, and retention of deciduous...

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PMID: 36435159
DOI: 10.1016/j.coi.2022.102264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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