Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression.

PloS one - 1 Jan 2015

Lamana Amalia, López-Santalla Mercedes, Castillo-González Raquel, Ortiz Ana María, Martín Javier, García-Vicuña Rosario, González-Álvaro Isidoro

Abstract excerpt

OBJECTIVE: The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. METHODS: We studied 201 patients (80% female; median age, 54 years; median disease duration, 5.4 months) from PEARL study. Demographic, clinical, laboratory and therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis
Share to Gene Expression Regulation
Share to Immunoenzyme Techniques
Share to Interleukin-6
Share to Longitudinal Studies
Share to Multivariate Analysis
Share to Real-Time Polymerase Chain Reaction
Share to STAT4 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 26569609
DOI: 10.1371/journal.pone.0142683
PMCID: PMC4646635

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression.PMID 26569609Read ↗

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.Semantic proximity Read ↗

STAT4 gene polymorphisms in human diseases.Semantic proximity Read ↗

Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis.Semantic proximity Read ↗

Association of STAT4 Gene Rs7574865, Rs10168266 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis.Semantic proximity Read ↗

The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.Semantic proximity Read ↗

Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.Semantic proximity Read ↗

STAT4 rs7574865 G/T polymorphism is associated with rheumatoid arthritis and disease activity, but not with anti-CCP antibody levels in a Mexican population.Semantic proximity Read ↗

An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression.Semantic proximity Read ↗

Association of STAT4 rs7574865 with susceptibility to systemic lupus erythematosus in Iranian population.Semantic proximity Read ↗

Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

STAT4: genetics, mechanisms, and implications for autoimmunity.Semantic proximity Read ↗

Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.