Variation in dinucleotide (GT) repeat sequence in the first exon of the <i>STAT6</i> gene is associated with atopic asthma and differentially regulates the promoter activity in vitro

Abstract excerpt

Upregulation of the IL-4/IL-13 mediated Th2 response is a characteristic of allergic diseases such as asthma, a common and often debilitating disease.1 STAT6 is a critical signalling molecule in the Th2 signalling pathway, and mice lacking STAT6 are protected from allergic pulmonary manifestations.2 The importance of STAT6 in asthma is also evident from studies showing that STAT6 gene expression is markedly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Asthma and respiratory diseases
• Share to Immunodeficiency and Autoimmune Disorders
• Share to Pediatric health and respiratory diseases