Article
Estimating time since infection in early homogeneous HIV-1 samples using a poisson model.
BMC bioinformatics - 25 Oct 2010
Giorgi Elena E, Funkhouser Bob, Athreya Gayathri, Perelson Alan S, Korber Bette T, Bhattacharya Tanmoy
Abstract excerpt
BACKGROUND: The occurrence of a genetic bottleneck in HIV sexual or mother-to-infant transmission has been well documented. This results in a majority of new infections being homogeneous, i.e., initiated by a single genetic strain. Early after infection, prior to the onset of the host immune response, the viral population grows exponentially. In this simple setting, an approach for estimating evolutionary and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.