Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation

30 Jul 2009

Abstract excerpt

Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory and proliferative cellular characteristics. Embryonic analyses demonstrated that initial MC specification and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cutaneous Melanoma Detection and Management
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19659570
DOI: 10.1111/j.1755-148x.2009.00616.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferationPMID 19659570Read ↗

PAX3 expression in normal skin melanocytes and melanocytic lesions (naevi and melanomas).Semantic proximity Read ↗

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration and suppress invasiveness, migration, and proliferation of melanoma cellsSemantic proximity Read ↗

Roles of endothelin signaling in melanocyte development and melanomaSemantic proximity Read ↗

Embryonic signaling in melanoma: potential for diagnosis and therapy.Semantic proximity Read ↗

Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to MelanomasSemantic proximity Read ↗

Association of galectin-3 expression with melanoma progression and prognosis.Semantic proximity Read ↗

GAB2 induces tumor angiogenesis in NRAS-driven melanoma.Semantic proximity Read ↗

Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in MelanocytesSemantic proximity Read ↗

erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.Semantic proximity Read ↗

B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2Semantic proximity Read ↗

Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest.Semantic proximity Read ↗

ERBB1/2/3 Expression, Prognosis, and Immune Infiltration in Cutaneous MelanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.