Article
Hematopoietic- and neurologic-expressed sequence 1 (Hn1) depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest.
Differentiation; research in biological diversity - 1 Jul 2009
Laughlin Katharine M, Luo Defang, Liu Che, Shaw Gerry, Warrington Kenneth H, Law Brian K, Harrison Jeffrey K
Abstract excerpt
The Hematopoietic- and neurologic-expressed sequence 1 (Hn1) gene encodes a small protein that is highly conserved among species. Hn1 expression is upregulated in regenerating neural tissues, including the axotomized adult rodent facial motor nerve and dedifferentiating retinal pigment epithelial cells of the Japanese newt. It is also expressed in numerous tissues during embryonic development as well as in...
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