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Article

Roles of endothelin signaling in melanocyte development and melanoma

1 Feb 2010

Abstract excerpt

Endothelin (Edn) signaling via the G-coupled, Edn receptor type B (Ednrb) is essential for the development of melanocytes from the neural crest (NC) and has been associated with melanoma progression. Edn3 plays varying roles during melanocyte development, promoting the proliferation and self-renewal of NC-derived multi- and bi-potential precursors as well as the survival, proliferation, differentiation and...

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PMID: 20128875
DOI: 10.1111/j.1755-148x.2010.00678.x

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