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Article

GAB2 induces tumor angiogenesis in NRAS-driven melanoma.

Oncogene - 1 Aug 2013

Yang Y, Wu J, Demir A, Castillo-Martin M, Melamed R D, Zhang G, Fukunaga-Kanabis M, Perez-Lorenzo R, Zheng B, Silvers D N, Brunner G, Wang S, Rabadan R, Cordon-Cardo C, Celebi J T

Abstract excerpt

GAB2 is a scaffold protein with diverse upstream and downstream effectors. MAPK and PI3K signaling pathways are known effectors of GAB2. It is amplified and overexpressed in a variety of human tumors including melanoma. Here we show a previously undescribed role for GAB2 in NRAS-driven melanoma....

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Share to GTP Phosphohydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22926523
DOI: 10.1038/onc.2012.367
PMCID: PMC3813964

Genes

GAB2
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22926523-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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