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Article

Prion proteins with pathogenic and protective mutations show similar structure and dynamics.

Biochemistry - 1 Sept 2009

Bae Sung-Hun, Legname Giuseppe, Serban Ana, Prusiner Stanley B, Wright Peter E, Dyson H Jane

Abstract excerpt

Conformational change in the prion protein (PrP) is thought to be responsible for a group of rare but fatal neurodegenerative diseases of humans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. However, little is known about the mechanism by which normal cellular PrPs initiate and propagate the conformational change. Here, we studied backbone dynamics of the inherited...

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Identifiers

PMID: 19618915
DOI: 10.1021/bi900923b
PMCID: PMC2762478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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