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Article

The elusive intermediate on the folding pathway of the prion protein.

The FEBS journal - 1 Mar 2008

Jenkins David C, Sylvester Ian D, Pinheiro Teresa J T

Abstract excerpt

A key molecular event in prion diseases is the conversion of the cellular conformation of the prion protein (PrP(C)) to an altered disease-associated form, generally denoted as scrapie isoform (PrP(Sc)). The molecular details of this conformational transition are not fully understood, but it has been suggested that an intermediate on the folding pathway of PrP(C) may be recruited to form PrP(Sc). In order to...

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Identifiers

PMID: 18279390
DOI: 10.1111/j.1742-4658.2008.06293.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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