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Article

Possible role of a radiation-induced p53 mutation in a Nelson's syndrome patient with a fatal outcome.

Pituitary - 1 Dec 2011

Pinto Emilia Modolo, Siqueira Sheila A C, Cukier Priscilla, Fragoso Maria C B V, Lin Chin Jia, de Mendonca Berenice Bilharinho

Abstract excerpt

Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. Such corticotroph macroadenomas respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein accumulation may be detected by...

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Identifiers

PMID: 19655257
DOI: 10.1007/s11102-009-0194-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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