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Article

Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene.

1 Jan 1996

Abstract excerpt

Nelson's syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing's disease. Extremely high plasma ACTH levels and aggressive neoplastic growth might be explained by the lack of appropriate glucocorticoid negative feedback due to defective glucocorticoid signal transduction. To study the glucocorticoid...

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Share to Adrenal Hormones and Disorders
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Identifiers

PMID: 8550738
DOI: 10.1210/jcem.81.1.8550738

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