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Article

Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

PloS one - 1 Jan 2012

Vaapil Marica, Helczynska Karolina, Villadsen René, Petersen Ole W, Johansson Elisabet, Beckman Siv, Larsson Christer, Påhlman Sven, Jögi Annika

Abstract excerpt

INTRODUCTION: Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences...

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Identifiers

PMID: 23029547
DOI: 10.1371/journal.pone.0046543
PMCID: PMC3460905

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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