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Article

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

Molecular and cellular biology - 1 Aug 2004

Morita Masashi, Stamp Gordon, Robins Peter, Dulic Anna, Rosewell Ian, Hrivnak Geza, Daly Graham, Lindahl Tomas, Barnes Deborah E

Abstract excerpt

TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely distributed in both proliferating and nonproliferating mammalian tissues. The cognate cDNA shows homology to the editing subunit of the Escherichia coli replicative DNA polymerase III holoenzyme and encodes an exonuclease which was able to serve a DNA-editing function in vitro, promoting...

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Source

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Identifiers

PMID: 15254239
DOI: 10.1128/MCB.24.15.6719-6727.2004
PMCID: PMC444847

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.PMID 15254239Read ↗

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The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.Semantic proximity Read ↗

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