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Article

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting.

Cells - 4 Nov 2020

Amin Azin, Perera Nirma D, Beart Philip M, Turner Bradley J, Shabanpoor Fazel

Abstract excerpt

Over the past 20 years, there has been a drastically increased understanding of the genetic basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different ALS-causing mutations, the accumulation of neurotoxic misfolded proteins, inclusions, and aggregates within motor neurons is the main pathological hallmark in all cases of ALS. These protein aggregates are proposed to disrupt...

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Identifiers

PMID: 33158177
DOI: 10.3390/cells9112413
PMCID: PMC7694295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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