Article
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
Human mutation - 1 May 2008
Bettens Karolien, Brouwers Nathalie, Engelborghs Sebastiaan, De Deyn Peter P, Van Broeckhoven Christine, Sleegers Kristel
Abstract excerpt
SORL1 has recently been identified as a major genetic contributor to increased risk for late-onset Alzheimer disease (AD). Here we aimed at replicating this finding in a large, well-characterized group of 550 Belgian late-onset AD patients and 637 healthy control individuals using a gene-wide genotyping approach across the SORL1 locus. We observed significant associations, both for individual SNPs (SNPs 6, 8, 9,...
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