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Article

Effect of natural killer T cell activation on initiation of atherosclerosis

1 Jan 2009

Abstract excerpt

It has been shown that natural killer T (NKT) cell activation accelerates atherosclerosis in apoE(-/-) mice. ApoE is, however, an important mediator in the presentation of lipids which may complicate conclusions on the role of NKT cells in atherosclerosis. Treatment of LDLr(-/-) mice with alpha-GalCer during Western-type diet feeding is therefore of interest. Atherosclerosis was induced by Western-type diet...

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Identifiers

PMID: 19652872
DOI: 10.1160/th09-01-0020

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