Article
Application of principal component analysis to pharmacogenomic studies in Canada.
The pharmacogenomics journal - 1 Dec 2009
Visscher H, Ross C J D, Dubé M-P, Brown A M K, Phillips M S, Carleton B C, Hayden M R
Abstract excerpt
Ethnicity can confound results in pharmacogenomic studies. Allele frequencies of loci that influence drug metabolism can vary substantially between different ethnicities and underlying ancestral genetic differences can lead to spurious findings in pharmacogenomic association studies. We evaluated the application of principal component analysis (PCA) in a pharmacogenomic study in Canada to detect and correct for...
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